Adrenergic Receptor Database
 
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Receptor List
Structure Info
Related Genes
Mutations
Ligand Info
Signal Pathway
Related Diseases
Targeted Drug
Distributions, Effects and Related Diseases of Adrnergic Receptors
Effector
Organs
Receptor
Type
Impulse Responses
Related Disease
Eye  
 Radial muscle,iris ¦Á1 Contraction (mydriasis) ++ Ocular Hypertension
Glaucoma
 Ciliary muscle ¦Â2 Relaxation for far vision +  
 
Heart ¦Á1;
¦Â1
¦Â2
Increase in heart rate, contractility and conduction velocity +++;
Regulation of cardiacmyocyte protein synthesis, growth and apoptosis.
Hypertension
Heart Failure
Angina Pectoris
Hypertrophy
Arrhythmia
(Bradycardia
Tachycardia)
AMI
 
Blood vessel  
 Arterioles (most) ¦Á1;¦Â2 Constriction +++; Dilatation + Hypertension
 Skeletal muscle
 arteriole
¦Á;¦Â2 Constriction +;    Dilatation ++  
 Veins(Systemic) ¦Á1,¦Á2;¦Â2 Constriction +++; Dilatation +  
 
Tracheal &
Bronchial muscle
¦Â2 Relaxation + Bronchial Asthma
Bronchospasm
Bronchitis
Bronchial glands ¦Á1;¦Â2 Decreased secretion; Increased secretion  
 
Salivary Glands ¦Á1 K+ & water secretion +
Amylase secretion +
 
Liver ¦Á1;¦Â2 Glycogenolysis & Gluconeogenesis +++  
Gallbladder ¦Â2 Relaxation +  
Stomach & Intestine ¦Á1,¦Á2;
¦Â2
Motility & ToneDecreased +;
Sphincters Contraction + 
 
Spleen Capsule ¦Á1;¦Â2 Contraction ++++; Relaxation +  
Pancreas
Islets (beta cells)
¦Á2;
¦Â2
Secretion Decreased +++;
Secretion Increased +
 
Fat Cells ¦Á2;¦Â1(¦Â3) Lipolysis +++ Obesity
 
Kidney ¦Á1;
¦Â1
Renin Secretion Decreased +;
Renin Secretion Increased ++
 
Urinary bladder  
 Detrusor ¦Â2 Relaxation +  
 Trigone & Sphincter ¦Á1 Contraction ++  
Ureter ¦Á1 Motility & Tone Increased +  
 
Uterus ¦Á1;¦Â2 Pregnant: Contraction(¦Á1); Relaxation(¦Â2);
Nonpregnant: Relaxation(¦Â2)
 
Sex Organs, Male ¦Á1 Ejaculation ++ Prostatic Hyperplasia
 
Skeletal Muscle ¦Â2 Contractility Increased +  
 
Skin  
 Pilomotor muscles ¦Á1 Contraction ++  
 Sweat glands ¦Á1 Localized Secretion +  
 
Note:
1. Receptor subtype in blue is the dominant one;
2. Please click on the hyperlink to view related references.
 
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