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Norepinephrine is the major neurotransmitter in
the peripheral sympathetic nervous system, whereas epinephrine is the primary
hormone secreted by the adrenal medulla in mammals. These two natural catecholamines
are involved in regulating a host of physiological functions, such as peripheral
excitation or inhibition of certain types of smooth muscles in different tissues
and organs, cardiac excitation, CNS modulation, metabolic and endocrine regulations.
Various subtypes of adrnergic receptors distributing over the body are critical
in the normally fulfillment of all these function. So, they are also involved
in the occurrence of many clinical disorders, such as hypertension, cardiovascular
shock, arrhythmias, asthma, migraine headaches, and anaphylactic reactions.
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